Background: Acetylsalicylic acid, clopidogrel and cilostazol are well-established agents inhibiting the
normal function of platelets with known advantages and limitations. The development of novel antiplatelet agents
aims to provide equal or superior outcomes for patients and simultaneously minimize side effects.
Objective: The aim of this manuscript is to review the latest data on the use of novel antiplatelet agents in vascular
Method: Based on our 2016 review, a further search in the English medical literature has yielded a number of
publications on cangrelor, prasugrel, ticagrelor, vorapaxar and a number of other – still experimental – agents (Ir-
6, UBO-QIC, W1, revacept and YM-254890).
Results: Recently published data have not altered the use and indications of cangrelor, prasugrel and vorapaxar;
all of them now approved by both FDA and EMA. The EUCLID trial has recently provided valuable data on the
clinical use of ticagrelor, although results regarding vascular patients and administration of ticagrelor are still
under scrutiny. Vorapaxar remains the only novel antiplatelet that is approved for PAD. Randomized control
trials that focus on vascular patients are necessary to establish the safety and efficacy of these novel agents. Despite
their positive initial results, most novel experimental antiplatelets are still in early development, thus in preclinical
or early clinical phases of their trials. Research on three novel antiplatelets is currently discontinued (atopaxar,
darexaban and elinogrel).
Conclusion: Vorapaxar remains the only novel antiplatelet that is approved for PAD. Other novel antiplatelets
demonstrate positive results, but further studies focused on vascular patients are necessary. Novel experimental
antiplatelets are still in the early phases of the clinical and preclinical studies.