Background: People suffer from fatal diseases which are responsible for mortality. Potent
devices and medicines are being developed to fight diseases caused by the microorganism for saving the
lives of individuals. Highly pathogenic viruses and bacteria are being incorporated into biological warfare,
which has become a major threat to mankind and causes the destruction of lives in a short span of
Objective: The pathogen Bacillus anthracis, which is the causative of anthrax, is used in bioterrorism.
Efforts are therefore being made to study the progress of biodefense drug discovery research in combating
Methods: This review describes the present status of the studies ontherapeutic measurement of anthrax
toxin inhibitors towards inhibition of protective antigen, lethal and edema factors using chemometric and
drug design tools to explore essential structural features for further design of active congeneric compounds.
Results: The inhibitors estimated to show high activity through different models may be proposed for
further synthesis and testing of biological activity in terms of anthrax toxin inhibition and cytotoxicity
testing by in vitro and in vivo assays.
Conclusion: Such an attempt is an insight of biodefense drug design against the dreadful threat to the
nation due to anthrax-based terrorism and biological warfare.