A series of substituted oxopropanylindole hydrazone derivatives was synthesized and evaluated
for anti-oxidant and anti-dyslipidemic activity. Of the 12 tested, 3 compounds (6c, 7b and 7d)
showed good anti-oxidant activity, compound 6c attenuated LDL oxidation by 32%. The compounds 6c
and 7d also showed good anti-dyslipidemic activity by reducing serum levels of total cholesterol (TC),
phospholipids (PL) and triglycerides (TG). These two compounds were further evaluated for antiadipogenic
and anti-hyperglycemic activity, where 6c showed 44% reduction in lipid accumulation and
20.5% and 24.3% reduction in blood glucose at 5h and 24h respectively, as compared to standard drug
metformin. Thus, compounds 6c and 7d with balanced anti-oxidant and anti-dyslipidimic activities may
be excellent candidates for lead optimization and drug development for the treatment of metabolic disorders.
Keywords: Hydrazone derivatives, Anti-oxidant, Anti-dyslipidemic, Atherosclerosis, Lipid, Anti-hyperglycemic.
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