Lipid Lowering Oxopropanylindole Hydrazone Derivatives with Antioxidant and Anti-hyperglycemic Activity

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Author(s): Kanika Varshney, Amit K. Gupta, Ravi Sonkar, Salil Varshney, Akanksha Mishra, Geetika Bhatia, Anil Gaikwad, Arvind Kumar Srivastava, Mridula Saxena, Sudha Jain*, Anil K. Saxena*.

Journal Name: Current Topics in Medicinal Chemistry

Abstract:

A series of substituted oxopropanylindole hydrazone derivatives was synthesized and evaluated for anti-oxidant and anti-dyslipidemic activity. Among these 12 compounds the three compounds 6c, 7b and 7d showed good anti-oxidant activity and the compound 6c attenuataed LDL oxidation by 32%. The compounds 6c and 7d also showed good anti-dyslipidemic activity by reducing serum levels of total cholesterol (TC), phospholipids (PL) and triglycerides (TG). These two compounds were further evaluated for anti-adipogenic and anti-hyperglycemic activity, where 6c was found most active compound with 44% reduction in lipid accumulation and 20.5% and 24.3% reduction in blood glucose at 5h and 24h respectively, as compared to standard drug metformin.

Keywords: Hydrazone derivatives; Anti-oxidant; Anti-dyslipidemic; Atherosclerosis.

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Article Details

(E-pub Ahead of Print)
DOI: 10.2174/1568026619666181220112903
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