Metastatic process has still not been completely elucidated,
probably due to insufficient knowledge of the underlying mechanisms. Here,
we provide an overview of the current findings that shed light on specific
molecular alterations associated with metastasis and present novel concepts
in the treatment of the metastatic process. In particular, we discuss novel
pharmacological approaches in the clinical setting that target metastatic
progression. New insights into the process of metastasis allow optimizing
and designing new treatment strategies, especially when taking into account
the fact that metastatic cells share common features with stem cells.
Lastly, we touch upon nano- and micro-technologies in targeted drug delivery
for metastatic cancer. The latter could provide more efficient way to tackle
metastasis and thus bring about advancements in the treatment and management
of cancer patients.
Keywords: metastasis, cancer stem cells, stem cell marker, nanomedicine,
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