Targeting tumour metastasis: the emerging role of nanotechnology

(E-pub Abstract Ahead of Print)

Author(s): Sarah Visentin, Mirela Sedić, Sandra Kraljević Pavelić, Krešimir Pavelić*.

Journal Name: Current Medicinal Chemistry

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Metastatic process has still not been completely elucidated, probably due to insufficient knowledge of the underlying mechanisms. Here, we provide an overview of the current findings that shed light on specific molecular alterations associated with metastasis and present novel concepts in the treatment of the metastatic process. In particular, we discuss novel pharmacological approaches in the clinical setting that target metastatic progression. New insights into the process of metastasis allow optimizing and designing new treatment strategies, especially when taking into account the fact that metastatic cells share common features with stem cells. Lastly, we touch upon nano- and micro-technologies in targeted drug delivery for metastatic cancer. The latter could provide more efficient way to tackle metastasis and thus bring about advancements in the treatment and management of cancer patients.

Keywords: metastasis, cancer stem cells, stem cell marker, nanomedicine, cancer therapy

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Article Details

(E-pub Abstract Ahead of Print)
DOI: 10.2174/0929867326666181220095343
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