Quinazoline is the six-membered heterocyclic ring system reported for its versatile biological
activities. This characteristic feature of quinazoline makes it a good template for a lead generation
library. Ring opening is one of the major concerns in the synthesis of quinazolin-4(3H)-one that results
in diamide formation. Here, alternative fusion strategy is reported, which is a time-saving and costeffective
method to overcome the ring opening problem associated with the synthesis of benzo[
d][1,3]oxazin-4-one and quinazolin-4(3H)-one.
Keywords: Quinazoline, ring opening, fusion, six-membered heterocyclic ring, fusion strategy, diamide formation.
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