Resolving the Mystery of Ring Opening in the Synthesis of Benzo[d][1, 3]oxazin-4-one and Quinazolin-4(3H)-one

Author(s): Harun Patel* , Rahul Pawara , Sanjay Surana .

Journal Name: Letters in Organic Chemistry

Volume 16 , Issue 11 , 2019

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Graphical Abstract:


Quinazoline is the six-membered heterocyclic ring system reported for its versatile biological activities. This characteristic feature of quinazoline makes it a good template for a lead generation library. Ring opening is one of the major concerns in the synthesis of quinazolin-4(3H)-one that results in diamide formation. Here, alternative fusion strategy is reported, which is a time-saving and costeffective method to overcome the ring opening problem associated with the synthesis of benzo[ d][1,3]oxazin-4-one and quinazolin-4(3H)-one.

Keywords: Quinazoline, ring opening, fusion, six-membered heterocyclic ring, fusion strategy, diamide formation.

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Article Details

Year: 2019
Page: [898 - 905]
Pages: 8
DOI: 10.2174/1570178616666181217114030
Price: $58

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