Recent Review on Subclass B1 Metallo-β-lactamases Inhibitors: Sword for Antimicrobial Resistance

Author(s): Aditi Kaushik*, Manish Kaushik, Viney Lather, J.S. Dua.

Journal Name: Current Drug Targets

Volume 20 , Issue 7 , 2019

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Abstract:

An emerging crisis of antibiotic resistance for microbial pathogens is alarming all the nations, posing a global threat to human health. The production of the metallo-β-lactamase enzyme is the most powerful strategy of bacteria to produce resistance. An efficient way to combat this global health threat is the development of broad/non-specific type of metallo-β-lactamase inhibitors, which can inhibit the different isoforms of the enzyme. Till date, there are no clinically active drugs against metallo- β-lactamase. The lack of efficient drug molecules against MBLs carrying bacteria requires continuous research efforts to overcome the problem of multidrug-resistance bacteria. The present review will discuss the clinically potent molecules against different variants of B1 metallo-β-lactamase.

Keywords: Antibiotic resistance, B1 metallo-β-lactamase, variants, enzyme, isoforms, multidrug-resistance bacteria.

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Article Details

VOLUME: 20
ISSUE: 7
Year: 2019
Page: [756 - 762]
Pages: 7
DOI: 10.2174/1389450120666181217101812
Price: $58

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