Anti-Obesity Drug Discovery and Development

Anti-Obesity Drug Discovery and Development

Volume: 4

Indexed in: Chemical Abstracts, EBSCO, Ulrich's Periodicals Directory, Scopus

Obesity is a complex health problem, caused by a number of factors such as excessive food intake, lack of physical activity, genetic predisposition, endocrine disorders, medications and psychiatric ...
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Anti-Obesity Molecules from Plants and their Mode of Action

Pp. 197-224 (28)

Megha Valsaraj, Navaneetha Saseendran, Arun Subash Koorapally and Anu Augustine

Abstract

Obesity is a chronic condition that is causally related to serious medical illnesses. Plants, especially those used in Ayurveda, can provide biologically active molecules and lead structures for the development of drugs with enhanced activity and reduced toxicity. Natural products, particularly medicinal plants, are believed to harbor potential anti-obesity agents that can act through various mechanisms, either by preventing weight gain, or by promoting weight loss. Their mechanisms of action include inhibition of key lipid and carbohydrate hydrolyzing and metabolizing enzymes, modification of serum lipoprotein and apolipoproteins, blockage of intestinal absorption, disruption of adipogenesis and adipogenic factors, suppression of appetite etc. The chapter gives an account of medicinal plants used in antiobesity drug formulations in Ayurveda and their mechanisms of action, like Holoptelea integrifolia, Averrhoa bilimbi, Terminalia chebula, Picrorhiza kurroa, Acorus calamus etc. The knowledge and detailed study about these plants will help to control obesity and to increase awareness on the importance of medicinal plants in addressing the issue.

Keywords:

Acorus calamus, Apolipoprotein, Averrhoea bilimbi and Terminalia chebula, Cholesterol, Chylomicrons, HDL, HMGR, Holoptelea integrifolia, LCAT, LDL, LPL, Lekhaneyagana, Obesity, Picrorhiza kurroa, VLDL.

Affiliation:

Department of Biotechnology and Microbiology, Kannur University, Thalassery Campus, India.