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Current Medicinal Chemistry

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ISSN (Online): 1875-533X

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Review Article

The Potential of Fucose-Containing Sulfated Polysaccharides As Scaffolds for Biomedical Applications

Author(s): Cláudia Nunes* and Manuel A. Coimbra

Volume 26, Issue 35, 2019

Page: [6399 - 6411] Pages: 13

DOI: 10.2174/0929867326666181213093718

Price: $65

Abstract

Marine environments have a high quantity and diversity of sulfated polysaccharides. In coastal regions brown algae are the most abundant biomass producers and their cell walls have fucosecontaining sulfated polysaccharides (FCSP), known as fucans and/or fucoidans. These sulfated compounds have been widely researched for their biomedical properties, namely the immunomodulatory, haemostasis, pathogen inhibition, anti-inflammatory capacity, and antitumoral. These activities are probably due to their ability to mimic the carbohydrate moieties of mammalian glycosaminoglycans. Therefore, the FCSP are interesting compounds for application in health-related subjects, mainly for developing scaffolds for delivery systems or tissue regeneration. FCSP showed potential for these applications also due to their ability to form stable 3D structures with other polymers able to entrap therapeutic agents or cell and growth factors, besides their biocompatibility and biodegradability. However, for the clinical use of these biopolymers well-defined reproducible molecules are required in order to accurately establish relationships between structural features and human health applications.

Keywords: Fucans, fucoidans, antitumoral, structural characteristics, delivery devices, tissue engineering.

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