Background: The understanding of protein function is essential to the study of biological
processes. However, the prediction of protein function has been a difficult task for bioinformatics to
overcome. This has resulted in many scholars focusing on the development of computational methods
to address this problem.
Objective: In this review, we introduce the recently developed computational methods of protein function
prediction and assess the validity of these methods. We then introduce the applications of clustering
methods in predicting protein functions.
Keywords: Clustering, protein function prediction, protein-protein interaction, protein complexes, computational methods.
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