Hypervalent Iodine-Mediated Synthesis of Spiroheterocycles via Oxidative Cyclization

(E-pub Ahead of Print)

Author(s): Linlin Xing, Yong Zhang, Yunfei Du*.

Journal Name: Current Organic Chemistry


Hypervalent iodine reagents have been widely used in the construction of many important building blocks and privileged scaffolds of bioactive natural products. This review article aims to briefly discuss strategies that have used hypervalent iodine reagents as oxidants to synthesize spiroheterocyclic compounds and to stimulate further study for novel syntheses of spiroheterocyclic core structures using hypervalent iodine reagents under metal-free conditions.

Keywords: hypervalent iodine reagents, spiroheterocycles, oxidative cyclization, metal-free conditions

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(E-pub Ahead of Print)
DOI: 10.2174/1385272822666181211122802
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