Hypervalent Iodine-Mediated Synthesis of Spiroheterocycles via Oxidative Cyclization

Author(s): Linlin Xing, Yong Zhang, Yunfei Du*.

Journal Name: Current Organic Chemistry

Volume 23 , Issue 1 , 2019

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Graphical Abstract:


Hypervalent iodine reagents have been widely used in the construction of many important building blocks and privileged scaffolds of bioactive natural products. This review article aims to briefly discuss strategies that have used hypervalent iodine reagents as oxidants to synthesize spiroheterocyclic compounds and to stimulate further study for novel syntheses of spiroheterocyclic core structures using hypervalent iodine reagents under metal-free conditions.

Keywords: Hypervalent iodine reagents, spiroheterocycles, oxidative cyclization, metal-free conditions, dearomatization, cascade annulation.

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Article Details

Year: 2019
Page: [14 - 37]
Pages: 24
DOI: 10.2174/1385272822666181211122802
Price: $58

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