Hybrid molecule approach of drug design has become popular due to advantages such as delayed
resistance, reduced toxicity, ease of treatment of co-infection and lower cost of preclinical
evaluation. Antifungal drugs currently available for the treatment of fungal diseases suffer a major side
effect of drug resistance. Hybrid drugs development is one of the approaches that has been employed
to control microbial resistance. Their antifungal activity is influenced by their design. This review is
focused on hybrid molecules exhibiting antifungal properties to guide scientists in search of more efficient
drugs for the treatment of fungal diseases.
Keywords: Heterocyclic compounds, hybrid compounds, antifungal, co-infection, preclinical evaluation, fungal diseases.
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