This review collects for the first time enantioselective domino reactions promoted
by chiral green copper catalysts, covering the literature since the beginning of
2006. It is divided into two parts dealing successively with asymmetric two-component
domino reactions and three-component processes. The first part is dedicated to twocomponent
asymmetric domino reactions, including Michael-initiated processes, domino
reactions based on cyclizations, domino reactions initiated by aldol-type condensations
and Friedel–Crafts-initiated domino processes. The second part collects asymmetric threecomponent
processes, such as Michael-initiated domino reactions, domino reactions between
alkynes, aldehydes and amines, domino reactions based on 1,3-dipolar cycloadditions
among the other three-component reactions.
Keywords: Enantioselective domino reactions, copper catalysis, metal catalysis, green chemistry, asymmetric catalysis, chirality.
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