Background: In the last decades, 3D-printing has been investigated and used intensively in the field of
tissue engineering, automotive and aerospace. With the first FDA approved printed medicinal product in 2015,
the research on 3D-printing for pharmaceutical application has attracted the attention of pharmaceutical scientists.
Due to its potential of fabricating complex structures and geometrics, it is a highly promising technology for
manufacturing individualized dosage forms. In addition, it enables the fabrication of dosage forms with tailored
drug release profiles.
Objective: The aim of this review article is to give a comprehensive overview of the used 3D-printing techniques
for pharmaceutical applications, including information about the required material, advantages and disadvantages
of the respective technique.
Methods: For the literature research, relevant keywords were identified and the literature was then thoroughly
Conclusion: The current status of 3D-printing as a manufacturing process for pharmaceutical dosage forms was
highlighted in this review article. Moreover, this article presents a critical evaluation of 3D-printing to control the
dose and drug release of printed dosage forms.