Background: With the development of nanotechnology, nanocarrier has widely been applied
in such fields as drug delivery, diagnostic and medical imaging and engineering in recent
years. Among all of the available nanocarriers, mesoporous silica nanoparticles (MSNs) have become
a hot issue because of their unique properties, such as large surface area and voidage, tunable
drug loading capacity and release kinetics, good biosafety and easily modified surface.
Objective: We described the most recent progress in silica-assisted drug delivery and biomedical applications
according to different types of Cargo in order to allow researchers to quickly learn about
the advance in this field.
Methods: Information has been collected from the recently published literature available mainly
through Title or Abstract search in SpringerLink and PubMed database. Special emphasis is on the
literature available during 2008-2017.
Results: In this review, the major research advances of MSNs on the drug delivery and biomedical
applications were summarized. The significant advantages of MSNs have also been listed. It was
found that the several significant challenges need to be addressed and investigated to further advance
the applications of these structurally defined nanomaterials.
Conclusion: Through approaching this review, the researchers can be aware of many new synthetic
methods, smart designs proposed in the recent year and remaining questions of MSNs at present.