Green Synthesis of Hydantoins and Derivatives

(E-pub Ahead of Print)

Author(s): Lluvia Itzel López-López*, Denisse de Loera*, Ernesto Rivera-Avalos, Aidé Sáenz-Galindo.

Journal Name: Mini-Reviews in Organic Chemistry

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Abstract:

The hydantoin moiety is found in several bioactive compounds with important pharmacological properties such as antimicrobial, antifungal, anti-androgens, anticancer and the historical action anticonvulsant. Because of these reasons, the synthesis of these compounds and their derivatives is important to review considering the philosophy of the green chemistry. In this review, we present the actual importance in the green synthesis of hydantoins and their derivatives using green methods, such as microwave and ultrasound irradiation, ionic liquids, solid-phase and solvent-free synthesis. Finally, several green protocols reported have been discussed.

Keywords: hydantoins, greeen sythesis, microwave, ultrasound, solid synthesis, free solvent synthesis

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Article Details

(E-pub Ahead of Print)
DOI: 10.2174/1570193X16666181206100225
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