The hydantoin moiety is found in several bioactive compounds with important pharmacological
properties such as antimicrobial, antifungal, anti-androgens, anticancer and the historical action
anticonvulsant. Because of these reasons, the synthesis of these compounds and their derivatives
is important to review considering the philosophy of the green chemistry. In this review, we present
the actual importance in the green synthesis of hydantoins and their derivatives using green methods,
such as microwave and ultrasound irradiation, ionic liquids, solid-phase and solvent-free synthesis.
Finally, several green protocols reported have been discussed.
Keywords: hydantoins, greeen sythesis, microwave, ultrasound, solid synthesis, free solvent synthesis
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