Advanced Non-Small Cell Lung Cancer with Activating Epidermal Growth Factor Receptor Mutation: First Line Treatment and Beyond

Author(s): Danilo Rocco, Ciro Battiloro, Luigi Della Gravara, Cesare Gridelli*.

Journal Name: Reviews on Recent Clinical Trials

Volume 14 , Issue 2 , 2019

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Graphical Abstract:


Background: Lung cancer is the leading cause of cancer mortality, being responsible for more than 1.6 million deaths each year worldwide and non-small-cell lung cancer (NSCLC) accounts for approximately 85% of lung cancers; moreover, 10 to 15% of all NSCLCs harbor EGFR (epidermal growth factor receptor) activating mutations, being suitable for EGFR-Tyrosine Kinase Inhibitors (TKI) molecular targeted therapy. However, EGFR+ NSCLCs gain acquired resistance to these agents, representing one of the key challenges for modern precision oncology.

Objective: Therefore, this paper aims to provide an extensive state of the art review, alongside with hints about future perspectives.

Conclusion: To date, in the light of the data from the FLAURA study, osimertinib represents the best first-line option in NSCLC patients with EGFR activating mutations; EGFR-TKI plus chemotherapy combination therapies, even though interesting, must still be considered investigational.

Keywords: Combination therapy, EGFR, NSCLC, Osimertinib, T790M, TKI.

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Year: 2019
Page: [120 - 128]
Pages: 9
DOI: 10.2174/1574887114666181205155211
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