Synthesis and Anti Lung Cancer Activity of 3-Arylspiro[oxirane-2,3'- thiochroman]-4'-one Derivatives

Author(s): Dhananjay Pandya, Yogesh Naliapara*.

Journal Name: Letters in Organic Chemistry

Volume 16 , Issue 6 , 2019

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A series of 3-arylspiro[oxirane-2,3'-thiochroman]-4'-one derivatives were synthesized and characterized by spectroscopy like 1H NMR, 13C NMR, mass spectrometry and elemental analysis. They were evaluated for their anti-lung cancer activity on human lung cancer cell line A-549 in DMSO. Compounds under study were found to be potent anti-lung cancer agents with GI50 values less than 10 with respect to positive control adriamycin.

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Article Details

Year: 2019
Page: [517 - 524]
Pages: 8
DOI: 10.2174/1570178616666181130163914
Price: $95

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