Synthesis and Anti Lung Cancer Activity of 3-Arylspiro[oxirane-2,3'- thiochroman]-4'-one Derivatives

Author(s): Dhananjay Pandya, Yogesh Naliapara*.

Journal Name: Letters in Organic Chemistry

Volume 16 , Issue 6 , 2019

Become EABM
Become Reviewer

Graphical Abstract:


Abstract:

A series of 3-arylspiro[oxirane-2,3'-thiochroman]-4'-one derivatives were synthesized and characterized by spectroscopy like 1H NMR, 13C NMR, mass spectrometry and elemental analysis. They were evaluated for their anti-lung cancer activity on human lung cancer cell line A-549 in DMSO. Compounds under study were found to be potent anti-lung cancer agents with GI50 values less than 10 with respect to positive control adriamycin.

Keywords: 3-Arylspiro[oxirane-2, 3' thiochroman]-4'-ones, α, β-epoxyketones, anticancer agents, epoxides, Darzen condensation, human lung cancer cell line A-549.

[1]
Ma, Z.; Zhang, X.; Wang, S.; He, Y.; Yang, G.; Li, B.; Yang, J.; Lu, Y.; Sun, J. Chin. J. Chem., 2011, 29, 757-764.
[2]
Zocher, F.; Enzelberger, M.M.; Bornscheuer, U.T.; Hauer, B.; Wohlleben, W.; Schmid, R.D. J. Biotechnol., 2000, 77, 287-292.
[3]
Nakazumi, H.; Ueyama, T.; Kitao, T. J. Heterocycl. Chem., 1984, 21, 193-196.
[4]
Hofmann, H.; Westernacher, H. Chem. Ber., 1969, 102, 205-222.
[5]
Maktedar, S.S.; Avashthi, G.; Singh, M. Ultrason. Sonochem., 2017, 34, 856-864.
[6]
Vichai, V.; Kirtikara, K. Nat. Protoc., 2006, 1, 1112-1116.
[7]
Skehan, P.; Storeng, R.; Scudiero, D.; Monks, A.; McMahon, J.; Vistica, D.; Warren, J.T.; Bokesch, H.; Kenney, S.; Boyd, M.R. J. Natl. Cancer Inst., 1990, 82, 1107-1112.
[8]
Khazi, I.A.M.; Gadad, A.K.; Mahajanshetti, C.S. Indian J. Heterocycl. Chem., 1995, 4, 243-248.
[9]
Hammam, A.E.G.; Fahmy, A.F.M.; Amr, A.E.; Mohamed, A.M. Indian J. Chem., 2003, 42B, 1985-1993.


Rights & PermissionsPrintExport Cite as

Article Details

VOLUME: 16
ISSUE: 6
Year: 2019
Page: [517 - 524]
Pages: 8
DOI: 10.2174/1570178616666181130163914
Price: $58

Article Metrics

PDF: 22
HTML: 3