Introduction: Renal Cell Carcinoma is a common type of renal cancer-causing deaths worldwide
which is characterized by sustained angiogenesis. VEGF and its receptors play a major role in
physiologic and pathologic angiogenesis, which is marked in tumour progression and metastasis development.
Induction of VEGF genes occur due to hypoxic condition induced by tumour growth after a critical
size in cancerous cell. Signal transduction networks originated by VEGFA/VEGFR2, (a notable
ligand-receptor complex in the VEGF system) leads to major angiogenesis events ranging from endothelial
cell proliferation, to new vessel formation, Furthermore, differential expression of VEGF-VEGFR
mRNA also found in different types of RCC.
Aim: The aim of present study is to inhibit the VEGFR2 protein by the action of certain inhibitors and
then to search an efficient inhibitor.
Materials and Methods: A total of 23 potential inhibitors were searched and used to target the protein
using the concept of molecular docking. Among 23 inhibitors, CHEMBL346631 shows best affinity with
the target protein and was used for high throughput virtual screening to find similar compounds. The
compound obtained from virtual screeningSCHEMBL469307, shows much more better affinity with
VEGFR2 than CHEMBL346631.
Conclusion: Relative study for both the compounds showed a minor difference in relevant properties. The
compound SCHEMBL469307 have a high potential to inhibit the VGFR2 protein and can be backed for
future studies in Renal Cell Carcinoma.