Metabolomic analysis has made substantial contributions to the understanding of diverse
pathological processes and has the potential to improve diagnosis and identify novel therapeutic targets.
As early success in perinatal medicine, nutrition, chronic diseases, cancer and trauma demonstrates,
metabolomics is approaching feasibility in terms of guiding improvement in population-level diagnosis
and treatment. A key barrier to implementing metabolomics as a routine diagnostic tool is rapid sample
extraction and data analysis along with the establishment of normal values for novel metabolic markers.
This review covers key advancements in clinical metabolomics and applies a high throughput metabolomics
method as a proof of principle to identify novel metabolites associated with remote
Keywords: Metabolomics, Remote ischemic preconditioning, Biomarker discovery, High-throughput screening, Clinical metabolomics
studies, Perinatal medicine.
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