Advances in In-silico B-cell Epitope Prediction

Author(s): Pingping Sun, Sijia Guo, Jiahang Sun, Liming Tan, Chang Lu, Zhiqiang Ma*.

Journal Name: Current Topics in Medicinal Chemistry

Volume 19 , Issue 2 , 2019

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Graphical Abstract:


Abstract:

Identification of B-cell epitopes in target antigens is one of the most crucial steps for epitopebased vaccine development, immunodiagnostic tests, antibody production, and disease diagnosis and therapy. Experimental methods for B-cell epitope mapping are time consuming, costly and labor intensive; in the meantime, various in-silico methods are proposed to predict both linear and conformational B-cell epitopes. The accurate identification of B-cell epitopes presents major challenges for immunoinformaticians. In this paper, we have comprehensively reviewed in-silico methods for B-cell epitope identification. The aim of this review is to stimulate the development of better tools which could improve the identification of B-cell epitopes, and further for the development of therapeutic antibodies and diagnostic tools.

Keywords: Epitope prediction, Linear epitope, Conformational epitope, BCR, B-cell, Epitope.

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VOLUME: 19
ISSUE: 2
Year: 2019
Page: [105 - 115]
Pages: 11
DOI: 10.2174/1568026619666181130111827
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