Designing of a Novel Indoline Scaffold Based Antibacterial Compound and Pharmacological Evaluation Using Chemoinformatics Approach

Author(s): Aarushi Singh, Neeraj Kumar, Damini Sood, Snigdha Singh, Amardeep Awasthi, Vartika Tomar, Ramesh Chandra*.

Journal Name: Current Topics in Medicinal Chemistry

Volume 18 , Issue 23 , 2018

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Abstract:

Antibiotic resistance is not only a global public health threat but also a huge economic burden to our society that urgently needs to be addressed by improved antibiotics and continuing development of novel molecules to treat resistant bacterial infections. Nowadays combination therapies offer a competent approach to counteract antibiotic resistance in bacteria. Better knowledge of mechanisms of antibiotic resistance has lead to the finding of new alternatives to antibiotic therapy. Hence, in this article, we report a novel series of indoline derivatives and their computational study as potent antimicrobials. The present study investigates the indoline based derived library interaction with DNA gyrase B enzyme to be used as a potential antimicrobial drug. Computational approaches were employed to carry out the molecular interactions and pharmacological studies. In this study, we have compared indoline with its derivatives and have found that compound 13 (1m) resulted in the strong binding with the highest score (-9.02 kcal/mol) in the designed library where indoline showed (-6.43 kcal/mol). Furthermore, molecular dynamics simulation run also confirmed the strongest interaction of a compound and target protein with less RMSD and RMSF deviation of the complex. Notably, the compound was also found to possess the good pharmacological properties and pharmacokinetic properties.

Keywords: Indoline derivatives, Molecular docking, Molecular dynamics simulation, Pharmacological evaluation, Chemoinformatic, RMAs.

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Article Details

VOLUME: 18
ISSUE: 23
Year: 2018
Page: [2056 - 2065]
Pages: 10
DOI: 10.2174/1568026619666181129125524
Price: $58

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