Topical Nanoemulgel for Skin Disorders: Formulation Approach and Characterization

(E-pub Ahead of Print)

Author(s): Javed Ahmad*, Anuj Gautam, Shahadali Komath, Mehdiya Bano, Anuj Garg, Keerti Jain.

Journal Name: Recent Patents on Anti-Infective Drug Discovery

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Backgrounds: Acne vulgaris is a common chronic skin disease that affects approximately 650 million people or about 9.4% of the population globally. Growing research in the area of nanotechnology over the years has now been exploited in the management of various human disorders by their application in drug delivery. These approaches have an enormous opportunity for the designing of a novel, low-dose and effective treatment systems to control acne disease. Topical nanoemulsion-based gel preparations are said to have various benefits over the conventional formulations. The recent patents on topical anti-acne formulation (US 7241456B2; US 6897238B2; US 6284234B1) provided the concept to design thymol loaded nano-emulgel for topical application in acne.

Methods: The aim of the present study was to design thymol loaded nano-emulgel preparation by exploiting low-energy emulsification method for topical application in acne. Furthermore, the developed formulation was characterized for thermodynamic stability, mean droplet size, zeta potential, drug content and in-vitro drug diffusion study.

Results: The optimized thymol loaded nanoemulsion was found to be 13.60±0.117 nm with PDI 0.197±0.008. Nanoemulsions will provide an enormous surface area for better penetration of the therapeutic agent into the pilosebaceous region, resulting in better efficacy.

Conclusion: From the above studies, it concluded that aqueous-based gel vehicle of the developed formulation system exploited for topical delivery has moisturising properties which can improve local tolerability also.

Keywords: Acne vulgaris, nanoemulsion, thymol, pilosebaceous region, topical delivery, moisturising properties.

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(E-pub Ahead of Print)
DOI: 10.2174/1574891X14666181129115213

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