Backgrounds: Acne vulgaris is a common chronic skin disease that affects approximately
650 million people or about 9.4% of the population globally. Growing research
in the area of nanotechnology over the years has now been exploited in the management of
various human disorders by their application in drug delivery. These approaches have an
enormous opportunity for the designing of a novel, low-dose and effective treatment systems
to control acne disease. Topical nanoemulsion-based gel preparations are said to have various
benefits over the conventional formulations. The recent patents on topical anti-acne formulation
(US 7241456B2; US 6897238B2; US 6284234B1) provided the concept to design
thymol loaded nano-emulgel for topical application in acne.
Methods: The aim of the present study was to design thymol loaded nano-emulgel preparation
by exploiting low-energy emulsification method for topical application in acne. Furthermore,
the developed formulation was characterized for thermodynamic stability, mean
droplet size, zeta potential, drug content and in-vitro drug diffusion study.
Results: The optimized thymol loaded nanoemulsion was found to be 13.60±0.117 nm with
PDI 0.197±0.008. Nanoemulsions will provide an enormous surface area for better penetration
of the therapeutic agent into the pilosebaceous region, resulting in better efficacy.
Conclusion: From the above studies, it concluded that aqueous-based gel vehicle of the developed
formulation system exploited for topical delivery has moisturising properties which
can improve local tolerability also.