Radiotherapy for Brain Tumors: Current Practice and Future Directions

(E-pub Ahead of Print)

Author(s): Sarah Baker, Natalie Logie, Kim Paulson, Adeleh Duimering, Albert Murtha*.

Journal Name: Current Cancer Therapy Reviews

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Radiotherapy is an important component of the treatment for primary and metastatic brain tumors. Due to the close proximity of critical structures and normal brain parenchyma, Central Nervous System (CNS) radiotherapy is associated with adverse effects such as neurocognitive deficits, which must be weighed against the benefit of improved tumor control. Advanced radiotherapy technology may help to mitigate toxicity risks, although there is a paucity of high-level evidence to support its use. Recent advances have been made in the treatment for gliomas, meningiomas, benign tumors, and metastases, although outcomes remain poor for many high grade tumors. This review highlights recent developments in CNS radiotherapy, discusses common treatment toxicities, critically reviews advanced radiotherapy technologies, and highlights promising treatment strategies to improve clinical outcomes in the future.

Keywords: Radiation, radiotherapy, brain tumor, central nervous system, intensity-modulated radiotherapy, proton therapy

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Article Details

(E-pub Ahead of Print)
DOI: 10.2174/1573394715666181129105542
Price: $95