Bradykinin Receptors in Ischemic Injury

Author(s): Min Tang*, Fangping He, Li Ma, Ping Liu, Jianwen Wang, Xiongchao Zhu.

Journal Name: Current Neurovascular Research

Volume 15 , Issue 4 , 2018

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Abstract:

Bradykinin (BK) is a major kinin substance in the Kallikrein-Kinin System (KKS) that acts in conjunction with target cell bradykinin receptors and is involved in a variety of systems and organs. Functional regulation and pathophysiological processes such as cardiovascular, renal, central nervous system regulation, glucose metabolism, cell proliferation, smooth muscle contraction, inflammation, pain, shock, and tissue damage processes, etc. The role and mechanism of receptors in the mediation of ischemic injury in tissues was reviewed.

Keywords: Kallikrein-Kinin System (KKS), Bradykinin (BK), B1 Receptor (B1R), B2 Receptor (B2R), myocardial ischemia, ischemia/reperfusion, hypoxia/reperfusion, angiogenesis, apoptosis.

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Article Details

VOLUME: 15
ISSUE: 4
Year: 2018
Page: [359 - 366]
Pages: 8
DOI: 10.2174/1567202616666181123151629
Price: $58

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