Abstract
Benzothiazole (BOT), the heterocyclic system consists of five-membered thiazole ring fused with the benzene ring. It is a very potent molecule because of its numerous pharmacological activities like anti-tumor, anti-microbial, anti-inflammatory, anticonvulsant, anti-diabetic, neuroprotective, calcium channel antagonist etc. Due to its extensive biological activities, it is still an interested area of research. Many scientists have discovered various methodologies for the synthesis of 2-aryl benzothiazoles and its derivatives by using different reaction conditions. 2-aryl benzothiazoles were synthesized via condensation of o-aminothiophenol with aldehydes. Previously, it had been synthesized using different types of catalysts to improve the selectivity, purity, and yield of the products. This review article mainly focuses on the synthesis of 2-arylbenzothiazoles using different reaction conditions from 2006 to 2018. This article is the detailed study of progressive environmental benign pathways for the synthetic strategies of 2-arylbenzothiazoles involving microwave assisted methods, ultra-sonication, use of nanoparticles, photo-assisted methods, metal catalysts, ionic liquids, mechanochemical grinding etc.
Keywords: 2-aryl benzothiazole, 2-aminothiophenol, aromatic aldehyde, green chemistry, nanoparticles, ionic liquids.
Graphical Abstract
Call for Papers in Thematic Issues
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This research area combines theoretical computation and screening with machine learning for the design of covalent/metal organic framework-based catalysts, bridging the disciplines of organic chemistry, physical chemistry, computational chemistry, materials science, and machine learning. It covers several critical aspects: designing and synthesizing organic catalysts for improved performance, applying computational methods ...read more
Carbohydrates conversion in biofuels and bioproducts
Biomass pretreatment, hydrolysis, and saccharification of carbohydrates, and sugars bioconversion in biofuels and bioproducts within a biorefinery framework. Carbohydrates derived from woody biomass, agricultural wastes, algae, sewage sludge, or any other lignocellulosic feedstock are included in this issue. Simulation, techno-economic analysis, and life cycle analysis of a biorefinery process are ...read more
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