Background: Microwave heating has been shown to be an invaluable technology for medicinal
chemistry and drug discovery applications. Recently, it has been used for heterocyclic synthesis
increasingly. This review article shows a work on the synthesis of coumarin derivatives by microwave-
Methods: Microwave-assisted heating has been used for the synthesis of coumarin derivatives. There
are some useful methods to obtain coumarin derivatives. The Knoevenagel condensation is the most
prominent one with microwave heating. The other one is the microwave-assisted Vilsmeier-Haack
reaction. Another one is microwave assisted convenient one-pot synthesis of coumarin derivatives
via Pechmann condensation catalyzed by FeF3 under solvent-free conditions. In addition to these,
Perkin condensation can also be used for the synthesis of coumarin derivatives under microwave
Results: Coumarin derivatives have a pharmacological importance in drug discovery and dyes. Microwave
irradiation is an effective method for the synthesis of coumarin derivatives and when compared
to the conventional heating, it has many advantages.
Conclusion: This review aimed to demonstrate the applications of microwave heating for the synthesis
of coumarin derivatives from 2007 to 2018. It may be helpful to synthesize new coumarin derivatives
as an alternative method that enables you to gain time and a new perspective.