Current Breakthroughs in Structure-based Design of Synthetic and Natural Sourced Inhibitors Against Zika Viral Targets

Author(s): Sisir Nandi*, Ramandeep Kaur, Mohit Kumar, Ankita Sharma, Aaliya Naaz, Subhash Chandra Mandal.

Journal Name: Current Topics in Medicinal Chemistry

Volume 18 , Issue 20 , 2018

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Abstract:

Background: Zika is a worldwide pandemic dreadful viral transmission through Aedes mosquito vector. It significantly causes fever, joint pain or rash, and conjunctivitis. Pregnant mothers suffering from Zika viral infection may have fetal abnormalities due to severe neurological problems, characterized by microcephaly along with Guillain-Barré syndrome, issuing ZIKV a major public health concern as declared by the World Health Organization. There is hardly any FDA approved anti-Zika viral drugs available.

Objective: Therefore, it is a big panic for the scientists to destroy the virus completely by generating potent inhibitors.

Methods: For the purpose, various Zika viral targets were explored by structure-based design in the present review in connection with the discovery of various synthetic and natural sourced inhibitors against Zika virus.

Results: The structure-based drug design tools such as x-ray crystallography and molecular docking reported various co-crystallized ligands and Zika virus inhibitors.

Conclusion: Such inhibitors could further be modified for the design of highly active leads to combat Zika virus utilizing chemoinformatics modules.

Keywords: Zika Virus (ZIKV), Potential Zika targets, Synthetic and natural sourced ZIKV inhibitors, Structure-based design, X-ray crystallography, Molecular docking.

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Article Details

VOLUME: 18
ISSUE: 20
Year: 2018
Page: [1792 - 1803]
Pages: 12
DOI: 10.2174/1568026619666181120125525
Price: $58

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