Title:Advancement in Nanotheranostics for Effective Skin Cancer Therapy: State of the Art
VOLUME: 8
Author(s):Md. Habban Akhter*, Mohamed Jawed Ahsan, Mahfoozur Rahman, Siraj Anwar and Md. Rizwanullah
Affiliation:Department of Pharmaceutics, School of Pharmaceutical Education and Research Jamia Hamdard (Hamdard University) New Delhi-110062, Department of Pharmaceutical Chemistry, Maharishi Arvind College of Pharmacy, Jaipur Rajasthan 302029, Department of Pharmaceutics, Shalom Institute of Health and Allied Sciences, SHUATS, 4Dept. of Pharmacology, School of Pharmaceutical Education and Research, Jamia Hamdard (Hamdard University) New Delhi-110062, Department of Pharmaceutics, School of Pharmaceutical Education and Research Jamia Hamdard (Hamdard University) New Delhi-110062
Keywords:Nanotheranostics, skin cancer
Abstract:The skin cancer has become a leading concern worldwide as a result of high
mortality rate. The treatment modality involves radiation therapy, chemotherapy or surgery.
More often combination therapy of chemotherapeutic agents gives better solution
over single chemotherapeutic agent. The Globocon report suggested that high incidence
and mortality rate in skin cancer are growing day-to-day. This type of cancer is more
prevalent in that area where a person is less exposed to sunlight. The nanotechnologybased
therapy is nowadays drawing attention and becoming a more important issue to be
discussed. The nanotherapy of skin cancer is dealt with various approaches and strategies.
The strategic based approaches involve nanoparticles targeting carcinoma cells, functionalized
nanoparticles for specific targeting to cancer cells, receptor-mediated active targeting
as nanoshells, nanostrutured lipid carriers, liposome, ethiosome, bilosome, polymeric
nanoparticle, nanosphere, denrimers, carbon nanotubes, quantum dots, solid lipid nanoparticles
and fullerenes which are highly efficient in specific killing of cancer cells. The
passive targeting of chemotherapeutic agents is also helpful in dealing with carcinoma
due to enhanced permeability and retention effect (EPR).
The article outlines nano-based therapy currently focused globally, and the outcomes of
the therapy as well.
