Synthesis of (E)-vinyl Isobutyronitriles via Fe(III)-catalyzed Decarboxylative Cross-coupling of Cinnamic Acids and AIBN under Additive-free Conditions

Author(s): Xuemei Xu, Zaigang Luo*, Yuyu Fang, Peng Liu.

Journal Name: Letters in Organic Chemistry

Volume 16 , Issue 8 , 2019

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Abstract:

A facile, efficient, additive-free and eco-friendly protocol for the synthesis of (E)-vinyl isobutyronitriles via Fe(III)-catalyzed decarboxylative cross-coupling of cinnamic acids and AIBN (azodiisobutyronitrile) has been developed. The presented methodology offers several advantages such as easy accessibility and stability of substrates, inexpensive catalyst and simple post-treatment procedure.

Keywords: Decarboxylative cross-coupling, cinnamic acids, AIBN, vinyl isobutyronitriles, additives, heterocycle.

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Article Details

VOLUME: 16
ISSUE: 8
Year: 2019
Page: [656 - 661]
Pages: 6
DOI: 10.2174/1570178616666181116112058
Price: $65

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