A Brief Survey of Machine Learning Methods in Protein Sub-Golgi Localization

Author(s): Wuritu Yang, Xiao-Juan Zhu, Jian Huang, Hui Ding, Hao Lin*.

Journal Name: Current Bioinformatics

Volume 14 , Issue 3 , 2019

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Abstract:

Background: The location of proteins in a cell can provide important clues to their functions in various biological processes. Thus, the application of machine learning method in the prediction of protein subcellular localization has become a hotspot in bioinformatics. As one of key organelles, the Golgi apparatus is in charge of protein storage, package, and distribution.

Objective: The identification of protein location in Golgi apparatus will provide in-depth insights into their functions. Thus, the machine learning-based method of predicting protein location in Golgi apparatus has been extensively explored. The development of protein sub-Golgi apparatus localization prediction should be reviewed for providing a whole background for the fields.

Method: The benchmark dataset, feature extraction, machine learning method and published results were summarized.

Results: We briefly introduced the recent progresses in protein sub-Golgi apparatus localization prediction using machine learning methods and discussed their advantages and disadvantages.

Conclusion: We pointed out the perspective of machine learning methods in protein sub-Golgi localization prediction.

Keywords: Golgi apparatus, machine learning method, feature vector, feature selection technique, webserver, benchmark dataset.

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VOLUME: 14
ISSUE: 3
Year: 2019
Page: [234 - 240]
Pages: 7
DOI: 10.2174/1574893613666181113131415
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