As the resistance to antimicrobial molecules increases among bacteria, the need for new antimicrobial
molecules increases. Antimicrobial peptides (AMP), which may be a new generation of antibiotic
candidates, are important in this respect. AMPs are small, cationic and amphipathic peptide sequences.
In eukaryotes, they are synthesized as a part of the immune system. Substantially, AMPs are
discovered in all kingdoms of life such as bacteria, fungi and protozoa. Approximately 3,000 AMPs
have been reported in the literature. However, most of these AMPs have been synthesized through
chemical synthesis. Nature has a huge source of microorganisms, and in the literature, there is a tendency
to increase every year the number of bacteria and fungus-derived AMPs thanks to their biotechnological
importance. The exploration of AMP and antibiofilm peptide (ABP) producer microorganisms
brings with it a lot of challenges experimentally. In this review study, we want to highlight the
importance and challenge of these natural peptides derived from microorganisms. We will also
propose a new explanation for ABPs.