Natural-based Antibiofilm and Antimicrobial Peptides from Microorganisms

Author(s): Aysenur Yazici, Serkan Ortucu*, Mesut Taskin, Lisa Marinelli.

Journal Name: Current Topics in Medicinal Chemistry

Volume 18 , Issue 24 , 2018

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Graphical Abstract:


As the resistance to antimicrobial molecules increases among bacteria, the need for new antimicrobial molecules increases. Antimicrobial peptides (AMP), which may be a new generation of antibiotic candidates, are important in this respect. AMPs are small, cationic and amphipathic peptide sequences. In eukaryotes, they are synthesized as a part of the immune system. Substantially, AMPs are discovered in all kingdoms of life such as bacteria, fungi and protozoa. Approximately 3,000 AMPs have been reported in the literature. However, most of these AMPs have been synthesized through chemical synthesis. Nature has a huge source of microorganisms, and in the literature, there is a tendency to increase every year the number of bacteria and fungus-derived AMPs thanks to their biotechnological importance. The exploration of AMP and antibiofilm peptide (ABP) producer microorganisms brings with it a lot of challenges experimentally. In this review study, we want to highlight the importance and challenge of these natural peptides derived from microorganisms. We will also propose a new explanation for ABPs.

Keywords: Antimicrobial peptide, Antibiofilm peptide, Production, Biofilm, Screening, Organisms.

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Article Details

Year: 2018
Page: [2102 - 2107]
Pages: 6
DOI: 10.2174/1568026618666181112143351
Price: $58

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PDF: 24
PRC: 1