Marine organisms are abundant sources of bioactive natural products. Among metabolites
produced by sponges and their associated microbial communities, halogenated natural compounds accounted
for an important part due to their potent biological activities. The present review updates and
compiles a total of 258 halogenated organic compounds isolated in the past three decades, especially
brominated derivatives derived from 31 genera of marine sponges. These compounds can be classified as
the following classes: brominated polyunsaturated lipids, nitrogen compounds, brominated tyrosine derivatives
and other halogenated compounds. These substances were listed together with their source organisms,
structures and bioactivities. For this purpose, 84 references were consulted.
Keywords: Halogenated, sponges, marine, isolate, constitutes, activity.
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