Title:Recent Advances in the Development of Polymeric Nanocarrier Formulations for the Treatment of Colon Cancer
VOLUME: 9 ISSUE: 1
Author(s):Sahil Kumar, Bandna Sharma, Kiran Thakur, Tilak R. Bhardwaj, Deo N. Prasad and Rajesh K. Singh*
Affiliation:Department of Pharmacy, School of Medical and Allied Sciences, GD Goenka University, Sohna, Dist. Gurugram- 122103, Haryana, School of Pharmacy & Emerging Sciences, Baddi University of Emerging Sciences & Technology, Baddi-173205, School of Pharmacy & Emerging Sciences, Baddi University of Emerging Sciences & Technology, Baddi-173205, School of Pharmacy & Emerging Sciences, Baddi University of Emerging Sciences & Technology, Baddi-173205, Department of Pharmaceutical Chemistry, Shivalik College of Pharmacy, Nangal, Distt. Rupnagar, Punjab, 140126, Department of Pharmaceutical Chemistry, Shivalik College of Pharmacy, Nangal, Distt. Rupnagar, Punjab, 140126
Keywords:Colon cancer, nanoparticles, nanocarriers, site-specific, polymers, anticancer drugs, cytotoxicity.
Abstract:Background: Many efforts have been explored in the last decade to treat colon cancer but
nanoparticulate drug delivery systems are making a vital contribution in the improvement of drug delivery
to colon cancer cells.
Objective: In this review, we attempt to highlight recent advancements in the development of novel
drug delivery systems of nanoparticles for the targeted drug delivery to colon. Polymers like Epithelial
Cell Adhesion Molecule (EpCAM) aptamer chitosan, Hyaluronic Acid (HA), Chitosan (CS)–
Carboxymethyl Starch (CMS), silsesquioxane capped mesoporous silica, Near IR (NIR) fluorescent
Human Serum Albumin (HAS), poly(ethylene glycol)-conjugated hyaluronic acid etc. have been discussed
by employing various anticancer drugs like doxorubicin, oxaliplatin, paclitaxel, 5-fluorouracil
etc.
Conclusion: These novel drug delivery systems have been determined to be more efficacious in terms
of stability, sustained and targeted drug delivery, therapeutic efficacy, improved bioavailability and enhanced
anticancer activity.
