Hybrid Magnetic Nanostructures For Cancer Diagnosis And Therapy

Author(s): Ioana L. Ardelean, Denisa Ficai*, Maria Sonmez, Ovidiu Oprea, Gheorghe Nechifor, Ecaterina Andronescu, Anton Ficai, Mihail A. Titu.

Journal Name: Anti-Cancer Agents in Medicinal Chemistry
(Formerly Current Medicinal Chemistry - Anti-Cancer Agents)

Volume 19 , Issue 1 , 2019

Become EABM
Become Reviewer

Graphical Abstract:


Abstract:

Cancer is the second disease in the world from the point of view of mortality. The conventional routes of treatment were found to be not sufficient and thus alternative ways are imposed. The use of hybrid, magnetic nanostructures is a promising way for simultaneous targeted diagnosis and treatment of various types of cancer. For this reason, the development of core@shell structures was found to be an efficient way to develop stable, biocompatible, non-toxic carriers with shell-dependent internalization capacity in cancer cells. So, the multicomponent approach can be the most suitable way to assure the multifunctionality of these nanostructures to achieve the desired/necessary properties. The in vivo stability is mostly assured by the coating of the magnetic core with various polymers (including polyethylene glycol, silica etc.), while the targeting capacity is mostly assured by the decoration of these nanostructures with folic acid. Unfortunately, there are also some limitations related to the multilayered approach. For instance, the increasing of the thickness of layers leads to a decrease the magnetic properties, (hyperthermia and guiding ability in the magnetic field, for instance), the outer shell should contain the targeting molecules (as well as the agents helping the internalization into the cancer cells), etc.

Keywords: SPIONs, cancer therapy, Drug Delivery System (DDS), hybrid magnetic nanostructures, hyperthermia, non-toxic carriers.

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VOLUME: 19
ISSUE: 1
Year: 2019
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DOI: 10.2174/1871520618666181109112655
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