Recent Advances in the Synthesis of Ferrocene-Based Heterocycles by Multicomponent Reactions: A Review

Author(s): Mahsa Shojaei Yeganeh, Fatemeh Abbasi, Ali Reza Kazemizadeh*.

Journal Name: Current Organic Chemistry

Volume 22 , Issue 26 , 2018

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Graphical Abstract:


Heterocycles are cyclic compounds with one or more heteroatom in their structures. They have various pharmaceutical applications. Incorporation of ferrocene scaffold into heterocyclic compounds can change the chemical and physiochemical properties of compounds. Ferrocene derivatives have a significant importance in pharmaceutical sciences like antibacterial, anticancer, antifungal, antiparasitic drug candidates, etc. Multicomponent reactions lead to simple and rapid procedures for the synthesis of organic compounds with molecular diversity. Multicomponent reactions have been used widely in heterocyclic synthesis, pharmaceutical chemistry, natural product synthesis, combinatorial chemistry, and polymer chemistry in the past two decades. This review deals with the synthesis of ferrocene-based heterocycles by multicomponent reactions.

Keywords: Multicomponent reactions, ferrocene, heterocycles, isocyanide, ferrocenecarbaldehyde, azetidine.

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Article Details

Year: 2018
Page: [2555 - 2575]
Pages: 21
DOI: 10.2174/1385272822666181109102607
Price: $58

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