Heterocycles are cyclic compounds with one or more heteroatom in their structures.
They have various pharmaceutical applications. Incorporation of ferrocene scaffold
into heterocyclic compounds can change the chemical and physiochemical properties of
compounds. Ferrocene derivatives have a significant importance in pharmaceutical sciences
like antibacterial, anticancer, antifungal, antiparasitic drug candidates, etc. Multicomponent
reactions lead to simple and rapid procedures for the synthesis of organic
compounds with molecular diversity. Multicomponent reactions have been used widely in
heterocyclic synthesis, pharmaceutical chemistry, natural product synthesis, combinatorial
chemistry, and polymer chemistry in the past two decades. This review deals with the synthesis
of ferrocene-based heterocycles by multicomponent reactions.
Keywords: Multicomponent reactions, ferrocene, heterocycles, isocyanide, ferrocenecarbaldehyde, azetidine.
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