AhR is an environmental response gene that mediates cellular responses to a variety of
xenobiotic compounds that frequently function as AhR ligands. Many AhR ligands are classified as
carcinogens or pro-carcinogens. Thus, AhR itself acts as a major mediator of the carcinogenic effect
of many xenobiotics in vivo. In this concise review, mechanisms by which AhR trans-activates downstream
target gene expression, modulates immune responses, and mediates malignant transformation
and tumor development are discussed. Moreover, activation of AhR by post-translational modifications
and crosstalk with other transcription factors or signaling pathways are also summarized.
Keywords: Aryl hydrocarbon receptor, xenobiotics, carcinogenesis, transcription factor, post-translation modification, review.
Rights & PermissionsPrintExport