Phosphomolybdic Acid (PMA)-catalyzed One-pot Synthesis of 2,3- Dihydroquinazolines

Author(s): Chuanhuan Chen, A. Xuejiao, Xia Li, Guoli Huang*, Bo Liu*.

Journal Name: Letters in Organic Chemistry

Volume 16 , Issue 8 , 2019

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Abstract:

We have developed a new method for the synthesis of 2,3-dihydroquinazolin-4(1H)-ones in good to excellent yields via phosphomolybdic acid (PMA)-catalyzed cyclocondensation of 2- aminobenzamides with aldehydes or ketones in N,N-dimethylformamide (DMF) at room temperature. The present method proves to be efficient in terms of short reaction time, high yield, simple workup and easy purification.

Keywords: 2, 3-dihydroquinazolinones, phosphomolybdic acid, 2-aminobenzamide, synthesis, ketone, aldehyde.

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Article Details

VOLUME: 16
ISSUE: 8
Year: 2019
Page: [683 - 687]
Pages: 5
DOI: 10.2174/1570178615666181108104155
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