Background: Pyrroles and fused pyrroles are of great interest as biologically active
compounds, among these activities; antidepressant activity is of special concern.
Objective: Synthesis of a series of pyrrolopyrazoles and their pyrimidine derivatives and their
characterization using spectral data to be monitored for antidepressant activity using behavioral
Method: A control group was administered the vehicle i.p., positive control group received
fluoxetine as standard and all other groups were administered the tested compounds. The groups
were subjected to tail suspension test (TST) to determine the antidepressant activity compared with
fluoxetine as a standard drug. The compounds exhibiting antidepressant activity were then used to
analyze changes in serotonin (5HT) level in the brain of albino mice.
Results: TST results showed that both pyrazoles and pyrazolopyrimidines derivatives exhibit
promising anti-depressant activity.
Conclusion: Compounds [pyrazoles & pyrazlopyrimidines] showed promising antidepressant activity
possibly mediated by the increased levels of 5HT.
Keywords: Anti-depressant assay, Pyrrolopyrazole, Pyrrole, Pyrazolopyrimidine , Synthesis, SAR, Antidepressant
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