Effects of Dietary Intake and Supplementation of Fatty Acids on Cardiometabolic Disorders in Humans: a Lesson from a Large Number of Meta-Analyses

(E-pub Ahead of Print)

Author(s): Sho-ichi Yamagishi*, Takanori Matsui.

Journal Name: Letters in Drug Design & Discovery

Become EABM
Become Reviewer


Dietary fatty acids have exerted numerous pathophysiological effects in humans. Indeed, monounsaturated fatty acids and ω-3 polyunsaturated fatty acids are generally thought to have favorable cardiometabolic actions via their anti-inflammatory and anti-thrombotic properties, while saturated fatty acids and trans fatty acids are supposed to contribute to the development and progression of atherosclerotic cardiovascular diseases by inducing dyslipidemia and obesity. However, there is much controversy about the effects of dietary intake and supplementation of fatty acids on cardiometabolic disorders. Therefore, in the present study, we limited the scope of this review to metaanalyses (1) of observational studies of dietary intake of fatty acids and (2) of interventional trials with fatty acid supplements to scrutinize the role of fatty acids in various cardiometabolic disorders. We discuss here the clinical effects of fatty acids from dietary intake or supplements on incidence of diabetes, metabolic syndrome, obesity and body weight, cardiovascular diseases and total mortality, and also review the association of fatty acid biomarkers with these cardiometabolic disorders.

Keywords: Cardiovascular disease, diabetes, fatty acids, meta-analysis, obesity, stroke.

Rights & PermissionsPrintExport Cite as

Article Details

(E-pub Ahead of Print)
DOI: 10.2174/1570180816666181107113148
Price: $95