Microwave-Assisted Synthesis of Chiral Oxime Ethers

Author(s): Asma Mehrez*, Dalila Mtat, Ridha Touati.

Journal Name: Letters in Organic Chemistry

Volume 16 , Issue 6 , 2019

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Abstract:

An efficient and rapid synthesis of a new class of chiral oxime ethers has been achieved via two-step reaction in which the first step is the reaction of oximes 1a-f with ethyl bromoacetate in the presence of sodium hydride to give oxime ethers 2a-f which are subsequently, in the second step, reacted with different commercially available chiral amines under microwave irradiation conditions to give compounds 3a-l in good to excellent yields. Through this method, we have observed a decrease in reaction time and excellent yields than the previously described conventional method.

Keywords: Oxime ethers, chiral, achiral, microwave irradiation, biological activity, growth regulators.

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Article Details

VOLUME: 16
ISSUE: 6
Year: 2019
Page: [495 - 500]
Pages: 6
DOI: 10.2174/1570178615666181106125853
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