Synthesis of (R)-2-benzylmorpholine employing catalytic stereospecific rearrangement of L-Phenylalaninol

Author(s): Mandapati Bhargava Reddy, Ramasamy Anandhan*.

Journal Name: Letters in Organic Chemistry

Volume 16 , Issue 8 , 2019

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Graphical Abstract:


Abstract:

An efficient synthesis of (R)-2-benzylmorpholine has been accomplished starting from L-phenylalaninol by employing stereospecific rearrangement of β-amino alcohol using catalytic amount of (CF3CO)2O as a key step.

Keywords: Morpholine, appetite suppressant agent, stereospecific rearrangement, debenzylation, alcohol, amine.

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The enantiopurity of amino alcohol 4 was measured by chiral HPLC analysis vide ref. 6b.


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Article Details

VOLUME: 16
ISSUE: 8
Year: 2019
Page: [633 - 636]
Pages: 4
DOI: 10.2174/1570178615666181105110940
Price: $65

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