Novel Topical Nanocarriers for Treatment of Psoriasis: An Overview

Author(s): Ankita Dadwal, Neeraj Mishra, Raj K. Narang*.

Journal Name: Current Pharmaceutical Design

Volume 24 , Issue 33 , 2018

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Abstract:

Background: Psoriasis is an autoimmune disease of the skin with lapsing episodes of hyperkeratosis, irritation and inflammation. Numerous methodologies and utilization of different antipsoriatic drugs with various activity methods and routes of administration have been investigated to treat this terrifying sickness. In any case, till date, there is no remedy for psoriasis because of the absence of an ideal carrier for effective and safe delivery of antipsoriatic drugs.

Objective: Among the different methods of medications for psoriasis, in the greater part of patients, topical treatment is most commonly utilized. For topical formulations, utilization of conventional excipients could fill the need just to a restricted degree. With the revelation of more up to date biocompatible and biodegradable materials like phospholipids, and Novel drug delivery technologies like liposomes, solid lipid nanoparticles (SLNs), microemulsions, and nanoemulsions, the possibility to enhance the efficiency and safety of the topical products has expanded to a great extent. Understanding the topical delivery aspects and that of outlining and creating different carrier systems have been enhanced that got further novelty to this approach.

Conclusion: Present review is an attempt to contemplate on psoriasis as far as improved comprehension of the dermal delivery perspectives and at present accessible treatment alternatives, significant preventions in psoriasis treatment, late advancements in the conveyance of different antipsoriatic drugs through novel colloidal drug transporters.

Keywords: Dermal drug delivery, liposomes, microemulsions, nanoemulsion, nanoparticles, phospholipids.

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Article Details

VOLUME: 24
ISSUE: 33
Year: 2018
Page: [3934 - 3950]
Pages: 17
DOI: 10.2174/1381612824666181102151507
Price: $58

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