Isolation of New Glycosides from Anemarrhena Asphodeloides Rhizome and Screening of their Anticancer Activity

Author(s): Pham Van Khang*, Nguyen Thi Hien Lan, Le Quang Truong, Mai Thi Minh Chau, Mai Xuan Truong, Dinh Thuy Van, Nguyen Thi Quynh Anh, Lei Ma*.

Journal Name: Letters in Organic Chemistry

Volume 16 , Issue 6 , 2019

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Abstract:

In this report, two new steroidal glycosides were isolated and determined from n-butanol fraction of A.asphodeloides. The structures were confirmed in comparison with the spectral data of known compounds by using different spectroscopic analysis approaches including 1D & 2D-NMR techniques and HRMS. The anti-proliferation screening against cancer cell lines A549 and HeLa indicated that compound 1 exhibited good inhibitory activities with IC50 values of 0.79 and 0.55 µg/mL, respectively.

Keywords: Anemarrhena asphodeloides, steroidal glycosides, HeLa, A549, anti-proliferation, cell line.

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Article Details

VOLUME: 16
ISSUE: 6
Year: 2019
Page: [474 - 477]
Pages: 4
DOI: 10.2174/1570178615666181102125553
Price: $65

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