Computational Modeling of Dielectrophoretic Microfluidic Channel for Simultaneous Separation of Red Blood Cells and Platelets

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Author(s): Praveenkumar S*, Srigitha S Nath, Dinesh Ram G, Ramesh R.

Journal Name: Current Signal Transduction Therapy

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Abstract:

In this paper, the design and computational modeling of microfluidic channel capable of separating platelets and red blood cell (RBC) from the other blood cells is proposed. Separation based on their sizes is made possible by utilizing negative dielectrophoretic (n-DEP) force in fusion with drag force. Array of 38º angled electrode separated by 70 µm distance is designed within the microchannel and analyzed for non-uniform electric field distribution. The molecule movement within the microchannel under induced electric field is simulated to demonstrate the separation using the particle trajectories module. Numerical study is performed for the calculation of Clausius Mossotti (CM) factor, n-DEP force and drag force.

Keywords: Microfluidics, Biomolecule separation, Dielectrophoresis, Computational Modeling, RBC, Platelets.

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Article Details

(E-pub Ahead of Print)
DOI: 10.2174/1574362413666181102113636