Background: Blood cytokines affect the development of inflammatory processes in both
normal and pathological states. We have studied changes in the concentration of interleukins (ILs) -
1β, IL-4, IL-10, IL-12B p40, transforming growth factor β (TGF β), tumor necrosis factor (TNF-α) in
acute carrageenan-induced inflammation and degenerative-dystrophic changes of knee joint caused
by monoiodoacetate-induced Osteoarthritis (OA) in experimental models on rats. We also investigated
the change in the cytokine profile during prophylactic and therapeutic administration of chondroitin
sulfate to animals under experimental conditions.
Methods: The concentration of the cytokines was measured in blood serum by enzyme-linked immunosorbent
Results: The manifestation of articular lesions was characterized by a disturbance in the balance between
proinflammatory (IL-1β, IL-12B p40, TNF-α) and anti-inflammatory (IL-4, IL-10, TGF -β)
Conclusion: A reduction in the concentration of proinflammatory cytokines in blood serum after
prophylactic and therapeutic administration of chondroitin sulfate to the rat with experimental models
of acute inflammation of the hind limb and degenerative-dystrophic changes in the knee joint
with OA is associated with anti-inflammatory and regenerative properties of the drug.