Marine sponges are a rich source of more than 50% of marine natural compounds that have
been isolated from marine organisms. This review article is focused on the importance of biologically
active and pharmaceutically important secondary metabolites extracted from one of the important
classes of marine sponge Hyrtios sp. This review also deals with reported synthetic routes of some indole
alkaloids extracted from the marine sponge Hyrtios sp. A range of bioactivities displayed by
indole-based alkaloids is described.
Keywords: Hyrtios sp., marine sponges, indole alkaloids, Hyrtinadine A, Hyrtiosin B, Asperazine.
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