This paper provides an overview of the pathogenesis, presentation and diagnosis of clopidogrel
hypersensitivity. The majority of clopidogrel hypersensitivity cases are due to a T cell mediated
Gell and Coombs Type IV reaction. History, histology, and patch testing have shown consistency with a
T cell mediated mechanism. Clopidogrel reactions most commonly present as a mild delayed maculopapular
erythematous rash 5 to 10 days after introduction of the drug, and do not always require discontinuation
of the drug. Severe cutaneous, systemic, and immediate adverse reactions to clopidogrel are
rare. For the diagnosis of clopidogrel hypersensitivity, drug causality can be determined using patch
testing, or for mild reactions, recurrence of symptoms after drug reintroduction, although neither are
required for diagnosis.
Keywords: Clopidogrel, hypersensitivity, pathogenesis, diagnosis, clopidogrel allergy, drug allergy.
Rights & PermissionsPrintExport